I upgraded from Linux Mint 21.3 to 22 today. It was definitely not fun.
It completely broke my WeeWx installation. I didn’t see anything in the release notes indicating the previous approach to installing python apps was now forbidden. Not knowing anything about the newer virtual env approach this took a long time to sort out. I checked the release notes just now and still see no mention of this.
In other news the update obliterated my SMB config file. At least that was a fairly quick fix.